This research mainly explored the causal relationships between two constructs; cultural Intelligence (CQ) and global Mindset (GM) that are important for individual and organization success in this globalized era. Besides the causal relationships between the two constructs which is the first research question, the second research questions was; “what is the CQ level of HR practitioners in Thailand?”, and the third research question was “how do age and gender influence the CQ level among HR practitioners in Thailand?”.